Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9

Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9

Blog Article

Long non-coding RNAs (lncRNAs) have been identified as influential indicators in variety of malignancies.Among which, LncRNA RUNDC3A-AS1 is reported to upregulate in thyroid cancer.However, the expression pattern and the pathological function of lncRNA RUNDC3A-AS1 in thyroid cancer is unclear.In this study, we examined the expression levels of lncRNA RUNDC3A-AS1 in the thyroid cancer tissues and cell lines via merlot redbud tree for sale RT-qPCR analysis.The effects of RUNDC3A-AS1 on thyroid cancer cell metastasis were detected by transwell chamber assay, scratch assay in vitro and lung metastasis model in vivo.

The results indicated that RUNDC3A-AS1 was highly expressed in the thyroid cancer tissues and cell lines.Functionally, knockdown of RUNDC3A-AS1 orange zinger tomato could repress the migration and invasion of thyroid cancer cells in vitro, and inhibit thyroid cancer metastasis to lung in vivo.Mechanistically, RUNDC3A-AS1 served as an inhibitor of miR-182-5p in tumor tissues and cell lines.RUNDC3A-AS1 inhibited the expression of miR-182-5p to increase the expression level of ADAM9, thus further aggravating the malignancy of thyroid cancer.Therefore, the RUNDC3A-AS1/miR-182-5p/ADAM9 axis may be a potential therapeutic target for the treatment of thyroid cancer metastasis.